Design, synthesis, spectral characterization and bioactivity evaluation of new sulfonamide and carbamate derivatives of 5-Nitro-1H-indazole

A series of new sulfonamide and carbamate derivatives of 5-nitro-1H-indazole was synthesized in good yields. The structures of all the newly synthesized compounds were confirmed by IR, 1H, 13C-NMR, Mass spectra and elemental analysis. The compounds 9a and 9f showed high antibacterial activity against L. bacillus and S. aureu, 9f and 9j exhibited good activity against E. coli and P. florescensa, whereas the compounds 9a, 9d. 9f and 9j showed good antifungal activity against tested fungal strains, however, compared to all the compounds 9e and 9h exhibited significant activity against A. niger and P.chrysogenum respectively.