Reaction of O-methylated flavones with semicarbazide: Serendipitous selective demethylation

Communication

JOURNAL 842

Organic Communications

VOLUME & ISSUE

Year: 2018 Issue: 2 April-June

PAGES

p.116 - 122

DOI ADDRESS

http://doi.org/10.25135/acg.oc.44.18.02.068

STATISTICS

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AUTHORS

Bala Murali Krishna Khandapu, Baby Ramana Mutchu, Vijaya Durga Thripuram, Naresh Polam , Rambabu Anandam , Ramesh Navudu and Hari Babu Bollikolla

GRAPHICAL ABSTRACT

ABSTRACT

An unusual reaction of selective demethylation of 5-O-methylated flavones, during the reaction with semicarbazide in glacial acetic acid, is reported. The generality of the method was ascertained for various 5-O-methylated flavones. However, the method is unsuitable for chalcones, flavanones, aurones, and acetophenones. Four different flavones including heterocyclic flavone were selectively demethylated and the products were characterized by their spectral data.

KEYWORDS

Flavones
semicarbazide
serendipitous
selective demethylation

SUPPORTING INFORMATION

Supporting Information

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