JOURNAL 466
Records of Natural Products
VOLUME & ISSUE
Year: 2012 Issue: 3 July September
Year: 2012 Issue: 3 July September
PAGES
p.242 - 254
p.242 - 254
STATISTICS
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Viewed 2153 times.
AUTHORS
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Bi Yi, Wang Tian, Meng Qingguo, Zhang Jiangfen, Wang Liang, Li Qiang, Zhao Fenglan and Sun Haijun
GRAPHICAL ABSTRACT
ABSTRACT
A series of ocotillol-type derivatives bearing a glycosyl moiety were synthesized. Among them, compound 3a and 3b led to a reduction in the increased CK, LDH, MDA activity and attenuate the decrease of SOD, GSH-PX and T-AOC compared with the iso group. In the heart section, compound 3aand 3b group showed nearly normal myofibrillar structure nearly without neutrophil granulocytes infiltration in the iso group. These results indicated that ocotillol-type derivatives may be the good lead compounds with protective property of myocardial ischemia.
KEYWORDS- Ocotillol-type derivatives
- myocardial ischemia
- synthesis
- ginsenoside.