JOURNAL 732


Records of Natural Products
VOLUME & ISSUE
Year: 2014 Issue: 2 April-June
PAGES
p.195 - 198
STATISTICS
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AUTHORS
    Rudiyansyah, Masriani, I. Wayan Mudianta and Mary J. Garson
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Boehmenan (1) is a lignan which has two feruloyl moieties at C-9 and C-9"' respectively. The structural characterization of (+)-boehmenan was confirmed by 1H-NMR, 13C NMR and HRESIMS as well as by direct comparison with the literature. CD measurements established a 7S' , 8R' configuration. Cytotoxicity evaluation showed that boehmenan is moderately active against the T47D cell line with IC 50 13.7 m g/mL and shows weak activity against the HeLa cancer cell line with IC 50 93.5 m g/mL. Boehmenan is also non-cytotoxic to the Vero cell line. From this study, boehmenan X and erythro-carolignan E were also obtained.

KEYWORDS
  • Bombacaceae
  • Boehmenan
  • Durio affinis
  • T47D cell .

SUPPORTING INFORMATION


Supporting Information
Download File Supp-25-RNP-1303-287.pdf (72.5 KB)