Isolation and Absolute Configuration of Boehmenan from Durio affinis Becc.
Records of Natural Products
Year: 2014 Issue: 2 April-June
p.195 - 198
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Rudiyansyah, Masriani, I. Wayan Mudianta and Mary J. Garson
Boehmenan (1) is a lignan which has two feruloyl moieties at C-9 and C-9"' respectively. The structural characterization of (+)-boehmenan was confirmed by 1H-NMR, 13C NMR and HRESIMS as well as by direct comparison with the literature. CD measurements established a 7S' , 8R' configuration. Cytotoxicity evaluation showed that boehmenan is moderately active against the T47D cell line with IC 50 13.7 m g/mL and shows weak activity against the HeLa cancer cell line with IC 50 93.5 m g/mL. Boehmenan is also non-cytotoxic to the Vero cell line. From this study, boehmenan X and erythro-carolignan E were also obtained.KEYWORDS
- Durio affinis
- T47D cell .