JOURNAL 347


Records of Natural Products
VOLUME & ISSUE
Year: 2016 Issue: 1 January-February
PAGES
p.109 - 112
STATISTICS
Viewed 1177 times.
AUTHORS
    Ki Yong Lee, Eun Ju Jeong, Sang Hyun Sung and Young Choong Kim
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A methanol extract of the roots of Stemona tuberosa (Stemonaceae) significantly inhibited lipopolysaccharide-induced nitric oxide production in murine BV2 microglial cells. Eight alkaloids tuberostemonine K (1), neotuberostemonine (2), oxotuberostemonine (3), bisdehydroneotuberostemonine (4), epibisdehydrotuberostemonine J (5), bisdehydrotuberostemonine (6), tuberostemoninol (7), and neostenine (8) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 4, 5 and 6 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 m M.

KEYWORDS
  • Stemona tuberose
  • alkaloids
  • lipopolysaccharide
  • BV2 microglia
  • nitric oxide