Bioactive Triterpenes from the Fungus Piptoporus betulinus
Records of Natural Products
Year: 2016 Issue: 1 January-February
p.103 - 108
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Zeyad Alresly, Ulrike Lindequist, Michael Lalk, Andrea Porzel, Norbert Arnold and Ludger A.Wessjohann
Phytochemical investigation of the ethyl acetate extract of the fruiting bodies from the basidiomycete Piptoporus betulinus led to the isolation of a new bioactive lanostane triterpene identified as 3 b -acetoxy-16-hydroxy-24-oxo-5α-lanosta-8- ene-21-oic acid (1). In addition, ten known triterpenes, polyporenic acid A (5), polyporenic acid C (4), three derivatives of polyporenic acid A (8, 10, 11), betulinic acid (3), betulin (2), ergosterol peroxide (6), 9,11-dehydroergosterol peroxide (7), and fomefficinic acid (9), were also isolated from the fungus. All isolated compounds were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria as well as against a fungal strain. The new triterpene and some of the other compounds showed antimicrobial activity against Gram-positive bacteria.KEYWORDS
- Piptoporus betulinus
- antibacterial activity
- iceman “Ötzi”.