JOURNAL 239


Records of Natural Products
VOLUME & ISSUE
Year: 2017 Issue: 3 May-June
PAGES
p.251 - 257
DOI ADDRESS
STATISTICS
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AUTHORS
    Shuen -Shin Yang, Ming-Jen Cheng, Hing-Yuen Chan, Sung-Yuan Hsieh, Ho-Cheng Wu, Gwo - Fang Yuan, Chu-Hung Lin, Hsun-Shuo Chang and Ih -Sheng Chen
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GRAPHICAL ABSTRACT


ABSTRACT


Eight benzenoids including three new phenols, piniphenols A–C (13), along with five known compounds, 4-vinylphenol (4) and 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl)ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8) were isolated from ethyl acetate layer of liquid fermentation with Porodaedalea pini (Hymenochaetaceae) BCRC 35384. All structures were established by spectral analysis and comparison with the literature data. Of these isolates, 1 showed moderate NO inhibitory activity with an IC 50 value of 60.0 μM . Compound 1 also showed the androgen receptor (AR) antagonism with the IC 50 value of 0.42 μM. To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea .

KEYWORDS
  • Porodaedalea pini
  • fungus
  • benzenoids
  • NO inhibitory activity
  • androgen antagonism.

SUPPORTING INFORMATION


Supporting Information
Download File 31-RNP-1611-540-SI.pdf (1.12 MB)