JOURNAL 1496


Records of Natural Products
VOLUME & ISSUE
Year: 2020 Issue: 4 July-August
PAGES
p.286 - 291
STATISTICS
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AUTHORS
  • Jue Li
  • Jianlin He
  • Chunai Yang
  • Xuelong Yan
  • Zhao Yin
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Two new lathyrane diterpenoids, euphofischers A and B (1 and 2), along with three known analogues (3-5), were isolated from the roots of Euphorbia fischeriana. Their structures were elucidated by spectroscopic analysis. Euphofischer A (1) represents rare example of a lathyrane diterpenoid featuring a 15-p-coumaroyl moiety. All compounds were screened for their cytotoxicity against three cancer cell lines (C4-2B, C42B/ENZR, and MDA-MB-231), and  compound 1 exhibited significant cytotoxicity against C4-2B cell line, with an IC50 value of 11.3 mM.

KEYWORDS
  • Euphorbia fischeriana
  • Euphorbiaceae
  • lathyrane
  • diterpenoid

SUPPORTING INFORMATION


Supporting Information
Download File A6-167-RNP-1912-1496-SI.pdf (1.49 MB)