JOURNAL 2437
Records of Natural Products
Year: 2023 Issue: 1 January-February
p.165 - 169
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Bingyao Huang
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Humu Lu
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Yanting Zhang
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Xia Gan
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Xueni Wang
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Yong-Hong Liu
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Xiaowei Luo
GRAPHICAL ABSTRACT
ABSTRACT
The Beibu Gulf represents an underexplored reservoir of marine micro-/organisms and secondary metabolites. Three uncommon 4-hydroxy-2-pyridone alkaloids and one phenazine alkaloid were obtained from the Beibu Gulf coral-associated fungus Acremonium sclerotigenum GXIMD 02501 via OSMAC approach. They were identified as campyridones D (1) and A (2), ilicicolin H (3), and phenazine-1-carboxylic acid (4), respectively, by spectroscopic analysis and comparison with literature values. All of them were evaluated for cytotoxic, anti-Vibrio, and NF-κB luciferase inhibitory activities. Compounds 2 and 3 showed cytotoxicity against two prostate cancer cell lines, with IC50 values of 17.6 ± 1.3 and 5.5 ± 1.2 μM for PC-3, while 25.4 ± 1.7 and 11.9 ± 1.3 μM for 22Rv1, respectively. Besides, compound 4 showed promising anti-Vibrio activity with MIC values of 0.047–0.067 mg/mL and also displayed inhibition of LPS-induced NF-κB activation at 10 μM.
KEYWORDS- Acremonium sclerotigenum
- coral-associated fungi
- alkaloids
- bioactivity
- cytotoxicity
