JOURNAL 2613
Records of Natural Products
Year: 2023 Issue: 4 July-August
p.715 - 720
Viewed 2101 times.
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Merdiye Mavis
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Manal Salah Babiker Ali
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Azmi Hanoğlu
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Yildiz Ozalp
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Dudu Özkum Yavuz
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Kemal Hüsnü Can Başer
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Nedime Serakinci
GRAPHICAL ABSTRACT
ABSTRACT
Aim of the study is to evaluate the potential use of Thymus capitatus (L.) Hoffm. & Link and Origanum dubium Boiss. essential oils and their major constituents; thymol and carvacrol in cancer therapies. For this aim hMSC-telo1 cells and their tumorigenic counterpart were exposed to varying concentrations of Thymus capitatus (L.) Hoffm. & Link and Origanum dubium Boiss. essential oils, thymol and carvacrol and cellular viability and proliferation have been evaluated by MTT assay. TUNEL assay has used for evaluation of apoptosis. Study suggested that, Thymus capitatus (L.) Hoffm. & Link essential oil and thymol have an enhancer effect once combined with conventional chemotherapeutic agents. 0.005 v/v % of Thymus capitatus (L.) Hoffm. & Link, 0.005 v/v % and 0.05 v/v % of thymol showed enchancer effect by sparing the normal hMSC-telo1 cells from the cytotoxicity of Deferasirox while these combinations were cytotoxic towards tumorigenic hMSC-telo1 cells.
KEYWORDS- Anticancer
- human mesenchymal stem cells
- tumorigenic
- essential oil
- thymol
- carvacrol
