Trichonafurin A: a New γ-Lactone Compound from the Marine-Derived Fungus Trichoderma atroviride ZW-7

Short Report

JOURNAL 2714

Records of Natural Products

VOLUME & ISSUE

Year: 2023 Issue: 4 July-August

PAGES

p.721 - 725

DOI ADDRESS

http://doi.org/10.25135/rnp.388.2302.2714

STATISTICS

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AUTHORS

Lu-Di Zhai
Wei Gao
Li-Ting Liu
Ke Zhang
De-Liang Zhang

GRAPHICAL ABSTRACT

ABSTRACT

A new γ-lactone compound, trichonafurin A (1), was obtained from the culture of Trichoderma atroviride ZW-7, an endophyte of the marine brown alga Sargassum thunbergii. Its structure was unambiguously assigned by detailed interpretation of 1D/2D NMR and HRESIMS data. Trichonafurin A (1) exhibited moderate cytotoxicity against HeLa and HepG2 cell lines with IC50 values of 20.2 and 32.1 μM, respectively.

KEYWORDS

Trichoderma atroviride
secondary metabolites
cytotoxic activity

SUPPORTING INFORMATION

Supporting Information

Download File A14-388-RNP-2302-2714-SI.pdf (1.21 MB)