A New Azaphilone Derivative from the Co-culture of Aspergillus versicolor and Aspergillus chevalieri

Short Report

JOURNAL 3391

Records of Natural Products

VOLUME & ISSUE

Year: 2025 Issue: 2 March-April

PAGES

p.198 - 203

DOI ADDRESS

http://doi.org/10.25135/rnp.507.2412.3391

STATISTICS

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AUTHORS

Jiao Li
Yuanjuan Wei
Guiyang Wang
Yan Li
Maoluo Gan

GRAPHICAL ABSTRACT

ABSTRACT

A new azaphilone derivative, namely aspergiphilone A (1), along with seven known compounds including lunatinin (2), (2S,3S)-5,6-dihydroxy-2,6-dimethyl-3-(2-oxopentyl)-2-cyclohexen-1-one (3), sterigmatocystin (4), glyantrypine (5), cottoquinazoline A (6), preechinulin (7), and (-)-neoechinulin (8), was obtained from co-cultures of two marine-derived fungi, Aspergillus versicolor IMB17-055 and A. chevalieri IMB18-208. Their structures were elucidated through MS, 1D, and 2D NMR analyses, combined with ECD calculations. Their inhibitory activity against mycobacterial CYP121, as well as their antimicrobial and cytotoxic activities, has been reported.

KEYWORDS

Aspergillus
azaphilone analogue
co-cultivation
secondary metabolites
marine fungus

SUPPORTING INFORMATION

Supporting Information

Download File A8-507-RNP-2412-3391-SI.pdf (1.79 MB)