JOURNAL 3456
Records of Natural Products
VOLUME & ISSUE
Year: 2025 Issue: 2 March-April
Year: 2025 Issue: 2 March-April
PAGES
p.193 - 197
p.193 - 197
STATISTICS
Viewed 220 times.
Viewed 220 times.
GRAPHICAL ABSTRACT
ABSTRACT
During the chemical studies on the target fungus Penicillium oxalicum 2021CDF-3, four compounds (1−4) were isolated and characterized from the culture of the solid rice medium. Their chemical structures were definitely determined by using HRESIMS and NMR experiments. Among them, compound 1 was reported as a new vetivane-type sesquiterpenoid bearing a tricyclic 7/5/5 framework. Compounds 1−4 were measured for their cytotoxicities against A549, MCF7, MKN-45, and HCT 116 cells. Compounds 2 and 4 displayed considerable inhibitory activity on the gastric cancer MKN-45 cell with IC50 values of 8.0 ± 0.5 and 11.9 ± 0.6 μM, respectively.
KEYWORDS- Penicillium oxalicum
- endophytic fungus
- secondary metabolites
- sesquiterpenoid
- cytotoxicity
