JOURNAL 3558
Records of Natural Products
VOLUME & ISSUE
Year: 2025 Issue: 5 September-October
Year: 2025 Issue: 5 September-October
PAGES
p.639 - 643
p.639 - 643
STATISTICS
Viewed 112 times.
Viewed 112 times.
GRAPHICAL ABSTRACT
ABSTRACT
Eight compounds were isolated from the 95% ethanol extract of Chloranthus serratus roots, including two monoterpenoid derivatives (1, 2), one pimarane-type diterpenoid (3), and five labdane-type diterpenoids (4-8). Compound 1 was identified as a previously undescribed camphene derivative, while compound 3 was a new natural product. Their structures and relative configurations were elucidated using HR-MS, NMR and ECD calculations. Compounds 1, 2, 5 significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells, with IC50 values of 17.47±1.24, 14.92±1.17, and 30.48±1.48 μM, respectively.
KEYWORDS- Chloranthus serratus
- monoterpenoid
- anti-inflammatory activity
