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A New Polyketide Derivative from the Nicotiana tabacum Symbiotic Fungus Aspergillus japonicus TE-739D

Short Report

JOURNAL 3561

Records of Natural Products
VOLUME & ISSUE
Year: 2025 Issue: 5 September-October
PAGES
p.633 - 638
DOI ADDRESS
http://doi.org/10.25135/rnp.541.2506.3561
STATISTICS
Viewed 818 times.
AUTHORS
  • Haisu Wang
  • Renji Gao
  • Xijin Liu
  • Xiaojie Bai
  • Long Jiang
  • Peng Zhang
  • Lei Zhan
  • Gan Gu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

biological effects. In our study chemical exploration of the Nicotiana tabacum symbiotic fungus Aspergillus japonicus TE-739D led to the discovery of a new polyketide derivative, namely (3S,4E,6E,9S)-9-hydroxy-3,7-dimethyldeca-4,6-dienoic acid (1), along with three previously reported compounds 2−4. The structures of these compounds were elucidated by using HRESIMS, NMR spectroscopic analyses, and quantum chemical calculations. Compounds 3 and 4 showed strong antibacterial activity against four representative bacterial strains including two Gram-negative species (Agrobacterium tumefaciens and Xanthomonas oryzae) and two Gram-positive Bacillus species (B. cereus and B. subtilis), with MIC values range from 1 to 16 μg/mL, respectively.

 KEYWORDS
  • Secondary metabolites
  • Aspergillus japonicus
  • polyketides
  • antibacterial activity

SUPPORTING INFORMATION

Supporting Information
Download File A7-541-RNP-2506-3561-SI.pdf (891 KB)