JOURNAL 3565
Records of Natural Products
VOLUME & ISSUE
Year: 2025 Issue: 5 September-October
Year: 2025 Issue: 5 September-October
PAGES
p.616 - 620
p.616 - 620
STATISTICS
Viewed 841 times.
Viewed 841 times.
GRAPHICAL ABSTRACT
ABSTRACT
Aconitaimine A, a new hetidine-type C20-diterpenoid alkaloid (1), and three known aconitine-type C19-diterpenoid alkaloids (2-4) were isolated from the roots of Aconitum taipeicum. The structures of all isolates were identified by spectroscopic methods and comparison with literature data. Compounds 1 and 2 showed inhibition of nitric oxide production in RAW 264.7 macrophages stimulated by lipopolysaccharide with IC50 values of 30.5 and 4.7 μM compared to positive control (dexamethasone, IC50 = 12.9 μM).
KEYWORDS- Aconitum taipeicum
- Ranunculaceae
- diterpenoid alkaloids
- NO inhibitory activity
