Cyclocarioside Z14, A New Dammarane Triterpenoid Glycoside from The Leaves of Cyclocarya paliurus with Cytotoxicity

Short Report

JOURNAL 3525

Records of Natural Products

VOLUME & ISSUE

Year: 2025 Issue: 5 September-October

PAGES

p.621 - 626

DOI ADDRESS

http://doi.org/10.25135/rnp.537.2505.3525

STATISTICS

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AUTHORS

Yijin Xu
Ruotong Liu
Qian Yao
Xifan Wei
Lu Wang
Fei Cheng

GRAPHICAL ABSTRACT

ABSTRACT

A new dammarane triterpenoid glycoside cyclocarioside Z14 (1) and four known compounds (2-5) were isolated from the dichloromethane extract of the leaves of Cyclocarya paliurus. The chemical structures were elucidated by the extensive spectroscopic data analysis of NMR, HR-ESI-MS, and acid hydrolysis. All isolated compounds were assayed on the cytotoxicity against seven human cancer cell lines. The compounds 1 and 3 showed moderate cytotoxicity against MCF-7 cells with an IC50 value of 29.51 μM and 33.88 μM.

KEYWORDS

Cyclocarya paliurus
dammarane triterpenoid glycoside
structural elucidation
cytotoxicity

SUPPORTING INFORMATION

Supporting Information

Download File A5-537-RNP-2505-3525-SI.pdf (1.53 MB)