Trichothecene Sesquiterpenes with Anti-osteosarcoma Cytotoxicity from the Fungus Fusarium sp. XPW68

Short Report

JOURNAL 3479

Records of Natural Products

VOLUME & ISSUE

Year: 2025 Issue: 6 November-December

PAGES

p.717 - 721

DOI ADDRESS

http://doi.org/10.25135/rnp.519.25.04.3479

STATISTICS

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AUTHORS

Huihuang Peng
Rui Chen
Yanxia Zhang
Linsa Zhou
Jie Lin

GRAPHICAL ABSTRACT

ABSTRACT

Fusarinene A (1), a previously undescribed trichothecene sesquiterpene, and three known compounds, 4β-hydroxytrichotheca-9,12-diene (2), trichodermol (3), and trichodermin (4), were isolated from the extract of Fusarium sp. XPW68. Their structures and relative configurations were identified by detailed analysis of nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. In the cytotoxic assay, compounds 1-4 exhibited selective or potent inhibition against five human osteosarcoma cell lines including 143B, MG-63, SaOS-2, SW1353, and U2OS, with IC50 values ranging from 0.8 to 48.2 μM.

KEYWORDS

Fusarium
trichothecene sesquiterpene
structure elucidation
cytotoxic activity

SUPPORTING INFORMATION

Supporting Information

Download File A5-519-RNP-2504-3479-SI.pdf (1.33 MB)