Mannodaidzein, a rare daidzein mannoside isolated froma rare actinomycete Saccharothrix sp. JS2

JOURNAL 3614

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Records of Natural Products

VOLUME & ISSUE

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Year: 2026 Issue: 1

PAGES

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p.12 - 12

DOI ADDRESS

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http://doi.org/10.25135/rnp.2508.3614

STATISTICS

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AUTHORS

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• Shan Lu
• Xinhang Su
• Lingling Ren
• Chengqian Pan
• Di Mao

PDF OF ARTICLE

GRAPHICAL ABSTRACT

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ABSTRACT

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A rare isoflavone mannoside, mannodaidzein (1), along with three known isoflavones (2–4), was isolated from the culture broth of an actinomycete Saccharothrix sp.JS2. Their chemical structures were determined by 1D/2D NMR and HR(ESI)MS data analyses. Among them, only compound 2 exhibited weak anti-proliferative activity against HT1080 cells at 100 µM. The structure-activity relationship analysis revealed that modification of the C-4' hydroxyl group adversely affected cytotoxicity. Mannodaidzein (1) represents the first mannoside of flavone.

KEYWORDS

• Isoflavone
• mannoside
• actinomycete
• cytotoxicity

SUPPORTING INFORMATION

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Supporting Information

Download File RNP-2508-3614-SI.doc (1.51 MB)