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GNPS molecular networking-guided discovery of antifungal butenolides from the endophytic fungus Aspergillus sp. FH-1 of Valeriana officinalis L.

Original Article

JOURNAL 3778

Records of Natural Products
VOLUME & ISSUE
Year: 2026 Issue: 3
PAGES
p.7 - 7
DOI ADDRESS
http://doi.org/10.25135/rnp.2512.3778
STATISTICS
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AUTHORS
  • Hao Fan
  • Xin Wang
  • Yinhan Teng
  • Pingping Wu
  • Haifang Wang
  • Yuze Li
  • Henglei Niu
  • Wei Wang
  • Xiaomei Song
  • Qing Chang
  • Dongdong Zhang
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Guided by an integrated GNPS molecular networking strategy, the chemical investigation of endophytic fungus Aspergillus sp. FH-1 (isolated from Valeriana officinalis L.) led to the discovery of four butenolides (1-4). Their structures were elucidated through comprehensive spectroscopic data analysis, including HRESIMS, 1D/2D NMR and ECD, revealing two new congeners, asperianas A (1) and B (2), along with the known analogues 3 and 4. Notably, compounds 1 and 3 exhibited significant antifungal activity against Colletotrichum gloeosporioides, with EC50 values of 19.23 ± 1.14 and 43.36 ± 1.12 μg/mL, respectively.

 KEYWORDS
  • Aspergillus sp. FH-1
  • GNPS molecular networking
  • butenolides
  • antifungal

SUPPORTING INFORMATION

Supporting Information
Download File RNP-2512-3778-SI.pdf (1.37 MB)