JOURNAL 3727
Records of Natural Products
Year: 2026 Issue: 4
p.5 - 5
Viewed 9 times.
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Y Thien Vu
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Thuc-Huy Duong
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Kiattawee Choowongkomon
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Chanat Aongbangkhen
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Thi-Thanh-Van Ho
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Hieu-Hien Nguyen
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Thi-Phuong Nguyen
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Ngoc-Hong Nguyen
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Thi-Phi-Giao Vo
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Thi-Hong-Trinh Nguyen
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Thi-Minh-Dinh Tran
GRAPHICAL ABSTRACT
ABSTRACT
Cultured lichen mycobionts have been considered as valuable sources of natural compounds with unique structure scaffolds. Nigrovothelium inspersotropicum, a crustose lichen from the family Trypetheliaceae, is an indigenous species in Vietnam. However, there is a scarcity of chemical and biological information available regarding N. inspersotropicum and its cultured mycobionts. In this study, the mycobiont of N. inspersotropicum was cultivated and subjected to chemical and biological investigations. As a result, six compounds, including 3,4-dihydro-7,8-dihydroxy-6-methoxy-3-methylisocoumarin (1), (+)-(3S)-6,7-dimethoxymellein (2), 8-hydroxy-6,7-dimethoxyisocoumarin (3), aspermytin A (4), subnudatone B (5), and b-sitosterol (6), were isolated and structurally elucidated using extensive spectroscopic analyses (1D- and 2D-NMR and HRESIMS). Notably, compound 1 is new compound, while compound 2 is identified as a new natural compound. The isolated compounds were evaluated for their inhibitory activities against alpha-glucosidase, nitric oxide production, SARS-CoV-2 Mpro, and HIV-1 reverse transcriptase. In summary, this study presents new information on natural compounds derived from the mycobiont of N. inspersotropicum and their promising anti-inflammatory, antihyperglycemic, and antiviral activities.
KEYWORDS- Nigrovothelium inspersotropicum
- isocoumarin
- alpha-glucosidase inhibition
- NO inhibition
- HIV-1 reverse transcriptase
