Organic Communications Articles
Issue: 3 July-September
Year: 2009 Volume: 2 Issue:3 July-September
1) B-Oxo anilides in heterocyclic synthesis: Synthesis of tri- and tetracyclic heteroaromatic containing a bridgehead nitrogen atom.
New heterocyclic compounds were synthesized using N-(benzo[d]thiazol-2-yl)-3-oxobutanamide (1) as starting material. The condensation of 1 with DMF-DMA by refluxing in xylene gave 3-Acetyl-2H-pyrimido[2,1-b][1,3]benzothiazol-2-one (3). Compound 3 was reacted with 2-cyanoethanethioamide, malononitrile, malononitrile/S, phenylhydrazine, and hydrazine to give new azoloazine derivativesKeywords Pyrimido[2 1-b][1 3]benzothiazol-2-one benzo[d]pyrido[2' 3':4 5]pyrimido[2 1-][1 3]thiazole-3-carbonitrile pyrazolo[3' 4':4 5]pyrimido[2 1-b][1 3] thiazole DETAILS PDF OF ARTICLE © 2009 ACG Publications. All rights reserved.
2) Microwave-assisted synthesis of 1,2-benzisoxazole derivatives in ionic liquid
A simple, highly efficient and environmentally benign method for the efficient conversion of 2-hydroxyalkyl/aryl ketoximes to 1,2-benzisoxazoles in the presence of catalytic amount of basic ionic liquid 1-butyl-3-methylimidazolium hydroxide ([bmim]OH) carried out under the influence of microwave irradiation. This method gives remarkable advantages such as short reaction times (30-60 sec), simple work-up procedure and excellent yields (85-96%). The ionic liquid was successfully reused for four cycles without significant loss of activity.Keywords 1 2-Benzisoxazole ketoxime ionic liquid microwave irradiation DETAILS PDF OF ARTICLE © 2009 ACG Publications. All rights reserved.
3) Epoxidation of cyclooctene and 1,5-cyclooctadiene by sodium perborate oxidation
Sodium perborate oxidizes cyclooctene and 1,5-Cyclooctadiene to form the corresponding epoxides in good yields under mild conditionsKeywords Cyclooctene 1 5-Cyclooctadiene epoxides sodium perborate sodium chloride DETAILS PDF OF ARTICLE © 2009 ACG Publications. All rights reserved.