Synthesis, characterization and antimicrobial activities of amide derivatives of febuxostat intermediate

Original Article

JOURNAL 772

Organic Communications

VOLUME & ISSUE

Year: 2015 Issue: 2 April-June

PAGES

p.43 - 51

STATISTICS

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AUTHORS

Sreedhar Badvel, Veera Reddy Tummaluru, Venugopal Reddy Katta, Vidya Sagar Reddy Gandi, Naga Raju Chamarthi and Padmavathi Venkatapuram

GRAPHICAL ABSTRACT

ABSTRACT

A series of new carboxamide derivatives of 3-(4-(5-(ethoxycarbonyl)-4-methylthiazol-2-yl)phenoxy)propionic acid were synthesized by Schotten-Baumann reaction. The newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. The target molecules were evaluated for their efficacy as antimicrobial agents in vitro by disc diffusion method. Compounds 4c, 4f, 4g and 4i showed high inhibitory activity.

KEYWORDS

Febuxostat intermediate
carboxamide derivatives
antimicrobial activity