Journal of Chemical Metrology

A scientific open access journal in the field of analytical chemistry and accreditation
Editor-in-Chief: Mustafa Özyürek
Editor-in-Chief: Ahmet C Goren
Book Review and Review Article Editor: John Warren

LATEST ARTICLES

Original Article

Determination of lead and beryllium in boron samples using 4-sulfamoylphenyl dithiocarbamate salt by ICP-OES

J. Chem. Metrol. (2024) in press ; 1 - 12
by Mustafa S. Dundar , Hatice Güçünlü , Celal Caner , Huseyin Altundag , Özcan Güleç and Mustafa Arslan

Today, high amounts of boron waste are generated due to the widespread use of boron and boron compounds. Boron waste in boron-producing enterprises in Türkiye reaches six hundred thousand tons annually. The utilization of boron wastes includes various stages, such as storage of refuse in appropriate places, recovery of boron from boron wastes, and utilization in proper sectors. In this study, the amounts of lead (Pb) and beryllium (Be) in three different boron samples (boron waste, boron ore, and processed boron ore) obtained from Kütahya-Emet region were determined by ICP-OES spectroscopic technique by cloud point extraction (CPE) method using 4-sulfamoylphenyl dithiocarbamate salt complexing agent. Colemanite was used as a boron ore in the study. According to the results, the optimum conditions for the recovery of lead and beryllium ions from aqueous media were found as pH=9, 0.12% (w/w) ligand, and 0.1% (w/w) surfactant concentration, 45 oC incubation temperature and 60 min incubation time. The RSD % of the method under the optimum conditions found were 2 and 2.5 for Pb2+ and Be2+, respectively. The procedure was successfully applied to boron waste samples, and Pb2+ and Be2+ recoveries between 96-105% were obtained.

DOI
http://doi.org/10.251135/jcm.110.2404.3183
Keywords
Boron waste boron ore processed boron ore 4-sulfamoylphenyl dithiocarbamate salt ICP-OES cloud point extraction
Available online: May 30, 2024
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Original Article

Trace element analysis in corn by cloud point extraction

J. Chem. Metrol. (2024) in press ; 1 - 11
by Mustafa S. Dundar , Sedef Arpaözü , Celal Caner , Huseyin Altundag , Özcan Güleç and Mustafa Arslan

In this study, Lead (Pb), Copper (Cu), and Tin (Sn) elements determined in corn samples were analyzed from three different regions of Sakarya province. A cloud point extraction (CPE) method was used for the metal determination study and analysis by inductively coupled plasma-optical emission spectroscopy (ICP-OES). In this study, optimization processes were performed in cloud point extraction 2-(4-sulphonylamidebenzo)hydrazide-1-dithiocarbamate salt as ligand and Triton X-114 as surfactant. Three different corn samples, soil samples, and certified reference materials (GBW10011 and GBW10012) were analyzed. Recovery values in corn samples were 95.5-97.1% for Cu, 101.8-105.2% for Pb, and 94.1-97.3% for Sn; Recovery values for soil samples were 99.3-104.3% for Cu, 93.6-103.3% for Pb and 99.5-101.6% for Sn detected among them.

DOI
http://doi.org/10.25135/jcm.109.2403.3180
Keywords
Corn trace element 2-(4-sulphonylamidebenzo)hydrazide-1-dithiocarbamate salt ICP-OES cloud point extraction (CPE).
Available online: May 11, 2024
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Original Article

Development of liquid chromatographic (LC) method for simultaneous estimation of novel anti diabetic drug Evogliptin and Metformin

J. Chem. Metrol. (2024) in press ; 1 - 10
by Deepanti Gajjar and Dimalkumar A Shah

Evogliptin and Metformin are antidiabetic medications. Evogliptin works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces the fasting and post-meal sugar levels. Metformin works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body's sensitivity to insulin. Accurate and precise high performance liquid chromatographic method has been developed for the estimation of Metformin and Evogliptin. Agilent C18 Column (250mm x 4.6mm, 5µm particle size) was used as stationary phase and methanol: 0.11% acetic acid in water (31: 69 % V/V) was used as mobile phase. The method was linear in the concentration range 50-250 µg/mL and 0.5 to 2.5 µg/mL of Metformin and Evogliptin respectively with a correlation coefficient of 0.999. The proposed method was validated with respect to linearity, accuracy, precision, and robustness as per International Council for Harmonisation of Technical Requirements of Pharmaceuticals for Human Use ICH Q2 (R2) guideline. The method was successfully applied for the analysis of Metformin and Evogliptin

DOI
http://doi.org/10.25135/jcm.108.2312.2989
Keywords
Metformin evogliptin design of experiment validation accuracy robustness
Available online: March 28, 2024
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Original Article

Novel analytical method development and validation for simultaneous estimation of curcumin, ascorbic acid and salicylic acid in bulk and its pharmaceutical formulation by RP-HPLC

J. Chem. Metrol. (2024) in press ; 1 - 9
by Manisha Jadav , Vandana Patel and Lalit Jha

A precise and specific reverse phase high-performance liquid chromatographic method has been developed and validated to quantify curcumin, ascorbic acid, and salicylic acid in both bulk and hydrogel. Utilizing a Hypersil BDS C18 column and an isocratic mode, the mobile phase comprised of a mixture of 0.1% orthophosphoric acid and acetonitrile (50:50 v/v). The calibration range spanned concentrations of 100 - 300 µg/mL for curcumin, 50 - 150 µg/mL for ascorbic acid and 50 - 150 µg/mL for salicylic acid. The specificity of the proposed method for estimating these compounds was established through chromatographic peak purity analysis. The limit of detection and the limit of quantification were found to be 18.54 µg/mL and 56.20 µg/mL for curcumin, 10.05 µg/mL and 30.46 µg/mL for ascorbic acid, and 11.39 µg/mL and 34.51 µg/mL for salicylic acid respectively. The accuracy of the method was demonstrated by recovering curcumin, ascorbic acid, and salicylic acid from the hydrogel formulation with a recovery rate exceeding 98%. This indicates the capability of the method to accurately estimate active pharmaceutical ingredients in hydrogel dosage form without interference from excipients. Validation results support the potential applicability of the proposed method for the quantitative estimation of these three drugs in hydrogel.

DOI
http://doi.org/10.25135/jcm.107.2310.2936
Keywords
High Performance liquid chromatography Hydrogel Method Development Curcumin Ascorbic acid Salicylic acid
Available online: March 15, 2024
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