A scientific open acces journal in the field of synthetic organic chemistry and polymers
Organic CommunicationsA scientific open acces journal in the field of synthetic organic chemistry and polymers
The synthesis of (E)-10-hydroxy-2-decenoic acid ethyl ester (10H2DA-EE) (3) was achieved via a one-pot, tandem oxidation-Wittig process from commercially available 1,8-octanediol (1), Wittig reagent (Ph3P=CHCO2Et) (2) and activated MnO2. Subsequent hydrolysis with sodium hydroxide gave (E)-10-hydroxy-2-decenoic acid (10H2DA) (4).Keywords One-pot tandem oxidation-Wittig process (E)-10-hydroxy-2-decenoic acid ethyl ester (E)-10-hydroxy-2decenoic DETAILS PDF OF ARTICLE © 2018 ACG Publications. All rights reserved.
One pot syntheses of six-, seven-membered cycloalkane and pyrane junctured aminocyanopyridines bearing furan unit were successfully prepared from the ketones, 2-((5-methylfuran-2-yl)methylene) malononitrile, and ammonium acetate. Photooxygenation of 2-(4-aminocyanopyridine) substituted 5-methylfurans gave 1,4-dicarbonyl functionalized aminocyanopyridine derivatives in good yield in one single operation.Keywords 4-Furyl-2-amino-3-cyanopyridines singlet oxygene 4-oxopent-2-enoylnicotinonitrile. DETAILS PDF OF ARTICLE © 2018 ACG Publications. All rights reserved.
A practical and efficient synthesis of non-spiro and spiropyrano[2,3-c]pyrazole-3-carboxylate derivatives was developed. The synthesis was achieved via a domino one-pot, four-component reaction of diethyl oxaloacetate, hydrazine, aldehyde and malanonitrile in refluxing acidic ethanolic solution under non-catalytic system. This method is rapid, simple and provides products in good yields and can be accessed via different classes of carbonyls, malanonitriles and hydrazine derivatives. Mechanistic study envisaged that this domino four-component reaction proceeds via sequential reactions of pyrazolone formation, Michael reaction and Thorpe-Ziegler cyclization reaction. Strong electronic effects of Knoevenagel and pyrozolone product contribute significantly towards successful cyclization of the title compounds.Keywords Pyrano[2 3-c]pyrazole-3-carboxylate diethyloxaloacetate Michael reaction DETAILS PDF OF ARTICLE © 2018 ACG Publications. All rights reserved.
A series of five –CH3, -NO2, -OCH3 and -Cl substituted 2-hydroxy-2,2-bis(4-phenyl)-N'-[(1E)-(3/4-phenyl)methylene]acetohydrazide (1a-1e) was synthesized by the reaction of 2-hydroxy-2,2-diphenylacetohydrazide with substituted aromatic aldehydes to give intermediate Schiff bases. Structures of the synthesized compounds were characterized using NMR (1D; 1H, 13C/APT and 2D 1H-1H COSY, and NOESY), FT-IR, UV, LC-MS/MS spectral data and elemental analysis. The geometry of compounds 1a-1e were determined to be “E” by NOESY. All the tested compounds showed cytotoxic activity on MCF-7 and PC-3 cell line at highest experimental concentration (100 µM). Compounds 1b (18.24 ± 7.62 µM) and 1e (7.62 ± 1.85 µM) have strong anti-proliferative activity on MCF-7 cell line, while compound 1b (45.81 ± 1.10 µM) has the strongest activity on PC-3 cell line.Keywords 2-Hydroxy-2 2-diphenylacetic acid acetohydrazide derivatives MCF-7 PC-3. DETAILS PDF OF ARTICLE © 2018 ACG Publications. All rights reserved.