Organic Communications

A scientific open acces journal in the field of synthetic organic chemistry and polymers
Editor-in-Chief: Hasan Seçen
Book Review and Review Article Editor: Turan Ozturk
Synthetic Polymer Section Editor: Mehmet S. Eroglu

LATEST ARTICLES

Original Article

Synthesis and cholinesterase inhibitory activity studies of some piperidinone derivatives

Org. Commun. (2019) in press ; 1 - 8
by Sulunay Parlar

AA series of a,β-unsaturated carbonyl based piperidinone derivatives were synthesized and evaluated for their abilities to inhibit AChE and BuChE. All compounds exhibited AChE and BuChE inhibitory activity in different ratios. Among the series, compound 1d, (1-benzyl-3,5-bis(4-nitrobenzylidene)piperidine-4-one), was found to be the most potent derivative against AChE (IC50= 12.55 µM) and compound 1g, (1-benzyl-3,5-bis(4-chlorobenzylidene)piperidine-4-one) showed the best anti-BuChE activity (IC50= 17.28 µM). The derivatives exhibited selectivity on AChE enzyme with respect to BuChE. Only compound 1g, bearing chlorine substituents, demonstrated as a dual inhibitor of cholinesterases. Taken together, these results indicated that a,β-unsaturated carbonyl based piperidinone scaffold might be a promising drug candidate for further anti-AD drug development.

DOI
http://doi.org/10.25135/acg.oc.69.19.09.1399
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Acetylcholinesterase inhibitors Butyrylcholinesterase inhibitors Piperidinone Alzheimer’s disease
Available online: November 04, 2019
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Short Communication

One-step transformation of a fluoro-based polymer into a superhydrophobic polymer composites

Org. Commun. (2019) in press ; 1 - 5
by Mehtap Evci and Tuncer Caykara

We describe the formation of superhydrophobic surfaces by controlling the surface roughness using some simple processing methods, such as annealing at 120 °C, freeze-drying at -40 °C and composite film preparation. The root-mean-square (rms) roughness and the water contact angle values of untreated poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12-heneicosaffluorododecyl acrylate) (PHFDA) film prepared on silicon substrate using spin-coating technique were about 1.35 nm and  θA/θR = 125o/103o , respectively. On the other hand, the annealed film at 120 °C and the freeze-dried film at -40 °C with only a small increase in the rms roughness and the water contact angle values were 2.05 nm and θA/θR = 126o/111o , and 2.28 nm and θA/θR = 130o/123o, respectively. However, these values for the composite film composed of PHFDA and active carbon were 2.54 nm and θA/θR = 165o/164o, respectively. This method can be applied to various surfaces as long as the composites composed of nanoparticles and polymeric materials do not cause any aggregation in spin-coating.

DOI
http://doi.org/10.25135/acg.oc.68.19.09.1403
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Superhydrophobic surfaces surface roughness composite film active carbon spin-coating
Available online: October 28, 2019
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Short Communication

Microvawe assisted synthesis of N-(methyl and methoxy) benzylidene-4-fluoroaniline derivatives and their carbonic anhydrase I and II inhibition properties

Org. Commun. (2019) in press ; 1 - 7
by Hülya Çelik and Müslüm Kuzu

IIn this study, some Schiff base derivatives (6a-f) were synthesized using a microwave method. The synthesized compounds were characterized by 1D, 2D NMR and mass spectral data. Their inhibitory effects were studied on carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-L-tyrosine-sulfanilamide affinity chromatography and the compounds N-3-Methylbenzylidene-4-fluoroaniline (6b), N-4-Methylbenzylidene-4-fluoroaniline (6c), N-2-Methoxybenzylidene-4-fluoroaniline (6d)  showed moderate activity on hCAII in the range of IC50 values.

DOI
http://doi.org/10.25135/acg.oc.66.19.07.1327
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Schiff base carbonic anhydrase N-benzylideneaniline NMR HRMS
Available online: October 24, 2019
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Original Article

Synthesis, characterization and theoretical studies of novel sulfonamide-aldehydes derivatives having tautomeric forms

Org. Commun. (2019) in press ; 1 - 12
by Mehmet Gümüş , Yusuf Sert and İrfan Koca

The newly synthesized six tautomeric aldehydes were characterized by 1H NMR and 13C NMR spectra. As a result of experimental characterization studies of target products, two tautomer structures named enol-azo and keto-hydrazo were observed. To support other experimental quantum chemical computations were utilized by Density Functional Theory using B3LYP functional and 6-311++G (d,p) basis set. All theoretical calculations were performed only for molecules M1 and M4 after each tautomer was optimized. The form III tautomers with lower energy of compounds M1 and M4 were determined as preferential structures in the ground state. From the MEP analysis, it is evident that the negative charge covers the C=O group and positive region is over the hydrogen groups. Finally, molecular docking calculations between 4F5S receptor and six ligand interactions were carried out by using AutoDock Vina program, and results were evaluated in detail.

DOI
http://doi.org/10.25135/acg.oc.67.19.09.1407
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Keto-hydrazo tautomer enol-azo tautomer sulfonamide DFT molecular docking GIAO
Available online: October 23, 2019
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