Records of Natural Products

A scientific open acces journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Honorary Editor: Ayhan Ulubelen
Co-Editor-in-Chief: Ahmet C Gören

LATEST ARTICLES

Original Article

Assessment of Endemic Cota fulvida (Asteraceae) for Phytochemical Composition and Inhibitory Activities against Oxidation, -Amylase, Lipoxygenase, Xanthine Oxidase and Tyrosinase Enzymes

Rec. Nat. Prod. (2018) in press ; 1 - 13
by Gulmira Özek , M. Ufuk Özbek , Süleyman Yur , Fatih Göger , Munevver Arslan and Temel Özek
Abstract

In the present work, chemical compositions of essential oil and methanol extract of endemic Cota fulvida (Grierson) Holub investigated as well as their antioxidant, antidiabetic, antiinflammatory and antimelanogenesis potent. The phytochemical analyses have been performed with GC-MS/FID and LC-MS/MS techniques. The essential oil was characterized with hexadecanoic acid (25.6 %), camphor (6.1 %), caryophyllene oxide (5.3 %), 1,8-cineole (4.9 %) and humulene epoxide (3.9 %). In the extract, phenolic acids, phenylpropanoid dimer and flavonoids were detected. The major constituents of the extracts were found to be 5-feruloylquinic acid, caftaric acid, 3,5-O-dicafeoylquinic acid and quercetin rutinoside. The antioxidant activities of the oil and extract were evaluated through scavenging of free radicals, inhibition of linoleic acid peroxidation and superoxide anion radical (O2-) generated by xanthine - xanthine oxidase (XO) system. The extract showed free radical scavenging activity (IC50 0.131 mg/mL), Trolox equivalent antioxidant capacity (1.33 mM) and inhibited (Inh. 36.3 %) peroxidation of lipids. The oil and extract demonstrated significant hypoglycemic activity via inhibition of porcine pancreatic a-amylase. The antiinflammatory effects of the oil and extract via inhibition of 5-LOX enzyme were found as 53.7 % and 23.9 %, respectively. The extract demonstrated moderate inhibitory effect (23.3 %) on oxidation of L-DOPA via inhibition of tyrosinase enzyme.

DOI
http://doi.org/10.25135/rnp.109.18.09.875
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Cota fulvida Essential Oil Extract GC-MS/FID LC-MS/MS Antioxidant
Available online: November 15, 2018
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Original Article

The Chemical Composition of Volatile Oil and Biological Activity of Rhododendron caucasicum

Rec. Nat. Prod. (2018) in press ; 1 - 8
by Seda Fandaklı , Nurettin Yaylı , Nuran Kahriman , Emel Uzunalioğlu , Nevin Ulaş Çolak , Sercan Yıldırım and Ahmet Yasar
Abstract

The aim of this research was to investigate the effect of different extraction methods on yield and chemical composition of essential oil from Rhododendrum caucasium. The volatiles of R. caucasicum have been isolated by hydro distillation (HD) and solid phase microextraction (SPME). The compositions of the essential oils were characterized by GC-FID and GC-MS. By HD and SPME, a total of twenty-five and thirty-one compounds were identified constituting over 89.25 %, and 90.33 % of oils composition, respectively. The main constituents of R. causacium were found to be calarene with ratios 46.13 % (HD), 54.91 (SPME) and sandaracopimaradine with ratios 25.93 % (HD), 8.16 % (SPME). In addition, the antimicrobial activity of isolated essential oils and obtained methanol and hexane extracts of plant formed the last part of study. According to results, HD essential oil showed moderate antimicrobial activities against Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus and Mycobacterium smegmatis. But other extracts showed not good antimicrobial activities.

DOI
http://doi.org/10.25135/rnp.107.18.09.952
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Rhododendron caucasicum; hydrodistillation; SPME; essential oil; antimicrobial activity; GC-FID/MS.
Available online: November 15, 2018
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Short Report

Glutinosine A: A New Morphinandienone Alkaloid from Litsea glutinosa

Rec. Nat. Prod. (2018) in press ; 1 - 4
by Yubin Ji, Chenxu Wang, Yuchen Zhang, Caiyun Zhang, Di Cui and Xiaopo Zhang
Abstract

A new morphinandienone alkaloid, named glutinosine A was isolated from the root barks of Litsea glutinosa. The new structure was determined by various spectroscopic techniques including 1D (1H-, 13C-NMR), 2D-NMR (HMBC, HSQC, COSY and ROESY) and high resolution electrospray ionization mass spectrometry (HR-ESI-MS). The effects of the new compound on glucose consumption in HepG2 cells were evaluated. Whereas, the result showed that this compound displayed no activity in stimulating glucose consumption.

DOI
http://doi.org/10.25135/rnp.92.18.06.306
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Litsea glutinosa Glutinosine A morphinandienone glucose consumption activities
Available online: November 12, 2018
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Short Report

Chemical composition of essential oils from leaves of six Piper species that grow in the Amazonia Biome, Brazil.

Rec. Nat. Prod. (2018) in press ; 1 - 9
by Claudio Augusto Gomes da Camara , Carolina Alves de Araujo , Marcilio Martins de Moraes , Geraldo José Nascimento de Vasconcelos , Charles Eugene Zartman and Marta Regina Silva Pereira
Abstract

Essential oils from the leaves of Piper japurense, P. coariense, P. auriculifolium, P. curtistilum, P. alatipetiolatum and P. brevesanum from the Amazon Forest (Brazil) were obtained through hydrodistillation. The chemical composition of the oils was determined using gas chromatography and mass spectrometry, which revealed the presence of 108 compounds representing 95.14 ± 0.35%, 95.64 ± 0.59%, 95.57 ± 0.48%, 92.05 ± 0.27%, 96.24 ± 1.04% and 91.31 ± 0.76% of the oils, respectively. The major components were α-eudesmol in the P. japurense (22.05 ± 0.15%) and P. coariense (27.33 ± 0.33%) oils, premnaspirodiene (32.26 ± 0.03%) in the P. auriculifolium oil, caryophyllene oxide (28.69 ± 0.17%) in the P. curtistilum oil, linalool (43.88 ± 0.50%) in the P. alatipetiolatum oil and β-elemene (12.75 ± 0.06%) in the P. brevesanum oil.

DOI
http://doi.org/10.25135/rnp.110.18.09.904
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Piper ssp Amazonia biome Essential oil Premnaspirodiene
Available online: November 12, 2018
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© ACG Publications. All rights reserved.