Records of Natural Products
A scientific open access journal in the field of natural products.
Records of Natural ProductsA scientific open access journal in the field of natural products.
Antimicrobial Effect and Antioxidant Activity of Triterpenes Isolated from Gymnema sylvestre R. Br.
Gymnema sylvestre is a commonly used herb in Ayurvedic medicine. The demand for its extracts in the commercial and pharmaceutical fields has been steadily increasing in recent years. Its extracts are used to treat various ailments as well as for their antimicrobial properties. This study has evaluated the antimicrobial effects of different G. sylvestre extracts and of eight triterpenes isolated from the most active extract on six bacterial poultry pathogens i.e. Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Enterobacter aerogenes. In particular, it has been evaluated the minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of all extracts and isolated triterpenes. Finally, the cytotoxicity activity of triterpenes was evaluated by MTT assay and their antioxidant activity in basal and oxidant conditions by DCFH-DA assay.DOI http://doi.org/10.25135/rnp.184.108.40.2068 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Gymnema sylvestre antimicrobial effects triterpenes gymnemic acids herbal drug DCFH-DA assay Available online: January 13, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Chemical Composition and Anticholinesterase Activity of the Essential Oil from the Ecuadorian Plant Salvia pichinchensis Benth
Salvia pichinchensis Benth was collected in the South of Ecuador and the essential oil (EO) was distilled from aerial parts and analyzed by GC-MS and GC-FID. The physical properties, chemical composition, and cholinesterase inhibitory activity were determined. Six major components, all sesquiterpenes, were identified: cis-cadina-1(6),4-diene (17.11%) (1),γ-curcumene (13.75%) (2), (E)-caryophyllene (12.58%) (3), (E,E)-α-farnesene (10.00%) (4), α-gurjunene (9.46%) (5) and allo-aromadendrene (6.96%) (6). The EO showed an interesting selective inhibitory activity against the enzyme butyrylcholinesterase (50.70 μg/mL) and only low inhibitory activity against acetylcholinesterase (117.60 μg/mL). The chemical composition and butyrylcholinesterase activity of the EO of S. pichinchensis Benth was reported for first time.DOI http://doi.org/10.25135/rnp.164.19.07.1342 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Salvia pichinchensis essential oil GC-MS analysis in vitro ChE inhibitory activity cis-cadina-1(6),4-diene Available online: January 09, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Novel Hopanoic Acid and Depside from the Lichen Dirinaria applanata
From the extract of lichen Dirinaria applanata, two hopane derivatives including 1b-acetoxy-3b-hydroxy-21a-hopan-29-oic acid (1), hopane-3b, 6b, 21a-triol (2) and a depside namely 2-O¢-methylnordivaricatic acid (3) were isolated and identified by extensive analyzing 1D-NMR, 2D-NMR, HRESI-MS, and FT-IR. Notably, compound 1 and 3 were novel compounds while compound 2 was isolated from this lichen species for the first time.DOI http://doi.org/10.25135/rnp.220.127.116.111 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Dirinaria applanata lichen hopan-29-oic acid depside Available online: January 02, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Two New Compounds from the Deep-Sea-Serived Fungus Aspergillus sp. YPGA8
Chemical examination of a fraction of the EtOAc extract of a marine-derived fungus Aspergillus sp. YPGA8 resulted in the isolation of two new compounds, namely aspertriols A-B (1-2). Compounds 1-2 possess an identical 2,3,4-trihydroxybutoxy moiety, which is rarely found in natural products. Their structures were determined by extensive analyses of spectroscopic data (1D and 2D NMR, HRESIMS). The bioassay study revealed that compounds 1 and 2 were inactive toward a-glucosidase.DOI http://doi.org/10.25135/rnp.18.104.22.1687 (DOI number will be activated after the manuscript has been available in an issue.) Keywords marine-derived fungus Aspergillus sp. YPGA8 aspertriols A-B isolation structure identification Available online: December 20, 2019 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.