JOURNAL 2653
Organic Communications
Year: 2023 Issue: 1 January-March
p.11 - 23
Viewed 786 times.
-
Pelin Süzgün
-
Sevil Şenkardeş
-
Merve Gürboğa
-
Özlem Bingöl Özakpınar
-
Ş.Güniz Küçükgüzel
GRAPHICAL ABSTRACT
ABSTRACT
In this study, the synthesis and characterization of 2-(2-fluorobiphenyl-4-yl)-N´-[(substituted methylene]propanehydrazides (3a-s) and 2-(2-fluoro-[1,1'-biphenyl]-4-yl)-N-(5-methyl-2-(substituted aryl)-4-oxothiazolidin-3-yl)propanamides (4a-s) are described and also the antiproliferative effect of the compounds on HT-29, HeLa, A549 and MCF-7 cancer cell lines is investigated. Additionally, mouse embryonic fibroblast cells NIH3T3 were also evaluated to determine the selectivity. The results showed that the identified compounds did not cause any toxicity against NIH3T3 cell line. Moreover, N-(2-(3,5-Bis(trifluoromethyl)phenyl)-5-methyl-4-oxothiazolidin-3-yl)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanamide (4h) had the most growth inhibitory effect (55.97% inhibition) on HT-29 colorectal adenocarcinoma cell line. The results obtained from the study show that the compound 4h, which has no cytotoxic effect on normal cells, may be an alternative in the treatment of colon cancer.
KEYWORDS- Hydrazone
- 4-thiazolidinone
- MTT
- antiproliferative activity
- flurbiprofen
