JOURNAL 2696
Organic Communications
VOLUME & ISSUE
Available Online: April 29,2023
Available Online: April 29,2023
PAGES
p.1 - 12
p.1 - 12
DOI ADDRESS
http://doi.org/10.25135/acg.oc.148.2302.2696 (DOI number will be activated after the manuscript has been available in an issue.)
http://doi.org/10.25135/acg.oc.148.2302.2696 (DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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GRAPHICAL ABSTRACT
ABSTRACT
A series of novel hybrid compounds was synthesized where 2′-hydroxyacetophenone and N-alkylated thiotetrazole were coupled via methylene spacers of different lengths. The structures of the compounds were characterized by spectroscopic techniques, including the 1H- and 13C-NMR, FT-IR, and HRMS methods. The antimicrobial activities of the title compounds were evaluated against clinical isolates of Gram-positive and negative bacterial and fungal species. All compounds showed a broad spectrum of antimicrobial activity and inhibited all bacteria and fungi that tested with MIC values ranging from 4 to 128 µg/ml. 4a and 5d were the most active antibacterial members.
KEYWORDS- Hydroxyacetophenone
- tetrazole
- hybrid
- antimicrobial activity
