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Two New 13-oxomilbemycins from a NTG-Induced Mutation Strain of Streptomyces avermitilis AVE-H39

Original Article

JOURNAL 2075

Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 3 May-June
PAGES
p.206 - 211
DOI ADDRESS
http://doi.org/10.25135/rnp.269.2105.2075
STATISTICS
Viewed 1467 times.
AUTHORS
  • Ji-Dong Wang
  • Bing Li
  • Shao-yong Zhang
  • Yi Wu
  • Wen-Sheng Xiang
  • Li-Qin Zhang
  • Huan Qi
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Two new 13-oxomilbemycins, 13-oxomilbemycin β3 (1) and 25-ethyl-13-oxomilbemycin β3 (2), were isolated from the broth of a NTG-induced mutation strain of Streptomyces avermitilis AVE-H39. The structures of 1 and 2 were determined based on MS and extensive NMR analysis. Compounds 1 and 2 possessed moderate nematocidal activity.

 KEYWORDS
  • Streptomyces avermitilis AVE-H39
  • NTG-induced mutation
  • 13-oxomilbemycins
  • nematocidal activity

SUPPORTING INFORMATION

Supporting Information
Download File A1-269-RNP-2105-2075-SI.pdf (950.99 KB)