JOURNAL 2097
Records of Natural Products
Year: 2022 Issue: 4 July-August
p.307 - 315
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Nguyen Ngoc Tuan
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Ping-chung Kuo
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Vu Dinh Hoang
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Vu Thi Hien
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Le Dang Quang
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Tran Trung Hieu
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Yue-chiun Li
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Nguyen Tan Thanh
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Tian-shung Wu
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Tran Dinh Thang
GRAPHICAL ABSTRACT
ABSTRACT
Eleven chemical constituents, including one new limonoid trichilinin G (1), were identified from the fruit extracts of M. azedarach. The structure of 1 was established by various spectroscopic and mass spectrometric analyses. Among the eleven isolated compounds, trichilinin G (1) and meliatoxin B1 (2) were examined for their antifungal activity against Fusarium oxysporum, Magnaporthe grisea, Phytophthora spp. (PS), and P. capsici (PC). Limonoid 2 showed the best antifungal activity against PS (IC50 = 103.8 µg/mL) and PC (IC50 < 62.5 µg/mL) in a dose-dependent manner. While limonoid 1 exhibited a weak to moderate activity against these Phytophthora species, F. oxysporum and M. grisea were less sensitive to the two compounds tested. The inhibitory effects of trichilinin G on superoxide anion generation and elastase release by human neutrophils were also assessed in cellular model and did not show significant activity.
KEYWORDS- Triterpenoid
- limonoid
- trichilinin
- antifungal
- anti-inflammatory
