Coumarins from the Dichloromethane Root Extract of Heptaptera triquetra and Their Cytotoxic Activities

Original Article

JOURNAL 2846

Records of Natural Products

VOLUME & ISSUE

Year: 2023 Issue: 6 November-December

PAGES

p.998 - 1005

DOI ADDRESS

http://doi.org/10.25135/rnp.415.2307.2846

STATISTICS

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AUTHORS

Fatma Tosun
John A. Beutler
Mahmut Miski

GRAPHICAL ABSTRACT

ABSTRACT

A known dihydrofuranocoumarin ester; deltoin (1), together with five known sesquiterpene coumarin ethers; umbelliprenin (2), farnesyl scopoletin (3), karatavicinol (4), colladonin (5), colladin (6), and a novel sesquiterpene coumarin ether; 14′-hydroxybadrakemin (7) were isolated from the cytotoxic dichloromethane extract of the roots of Heptaptera triquetra. The cytotoxic activity of the isolated coumarins were evaluated against COLO205 (colon), KM12 (colon), A498 (renal) and UO31 (renal) cancer cell lines.

KEYWORDS

Heptaptera triquetra
Apiaceae
coumarins
cytotoxic activity

SUPPORTING INFORMATION

Supporting Information

Download File A3-415-RNP-2307-2846-SI.pdf (2.74 MB)