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Inhibition of the NLRP3 inflammasome by Callinudin A: A novel 3,4-seco-labdane diterpenoid derived from Callicarpa nudiflora

Short Report

JOURNAL 3770

Records of Natural Products
VOLUME & ISSUE
Year: 2026 Issue: 4
PAGES
p.3 - 3
DOI ADDRESS
http://doi.org/10.25135/rnp.2512.3770
STATISTICS
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AUTHORS
  • Xiaofeng Zhang
  • Tali Mei
  • Xuemei Luo
  • Jinye Yan
  • Yong Wang
  • Xiaowen He
  • Jinping Cai
  • Lin Dong
  • Qinghu Wang
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

 A previously uncharacterized 3,4-seco-labdane diterpenoid, which is designated Callinudin A (1), along with two known diterpenoids of the same type (2, 3), was isolated from Callicarpa nudiflora leaves. Multiple spectroscopic techniques and literature comparisons were used to elucidate the structures of these compounds. Furthermore, these compounds were tested in vitro to assess their effects on the NLRP3 inflammasome in lipopolysaccharide (LPS)-induced THP-1 macrophages. Analysis revealed that these compounds exhibit inhibitory effects on the NLRP3 inflammasome.

 KEYWORDS
  • Callicarpa nudiflora
  • Callinudin A
  • 3,4-seco-labdane diterpenoid
  • NLRP3 inflammasome

SUPPORTING INFORMATION

Supporting Information
Download File RNP-2512-3770-SI.pdf (1.91 MB)