A New Acyclic Compound from the Medicinal Plant Tinospora sinensis

In this study, chemical investigation of the aerial parts of the medicinal plant Tinospora sinensis yielded five compounds (1-5), including a new acyclic compound (1) and four known compounds (2-5). Their structures were determined by extensive analysis of the spectroscopic data, including 1D (1H and 13C NMR) and 2D NMR data (HSQC, COSY, and HMBC). Compounds 3-5 were identified to be stearic acid (3), abscisic acid (4), and blumenol A (5) based on comparisons of the NMR data with those reported in the literature. The NMR data for 2-hydroxy methyl stearate (2) were reported for the first time in CDCl3 in this study. The compounds were evaluated for their antitumor potential against A549 cell line, while all were inactive (25 mM). Besides, compound 1 demonstrated marginal inhibition (19.35%) of LPS-induced NO production in RAW 264.7 cells (50 mM).