Organic Communications

Year: 2012 Volume: 5 Issue:1 January-March

Original Article

1) Facile synthesis of some novel 2-substituted-4,6-diarylpyrimidines using 4 ' -hydroxy-3 ' ,5 ' -dinitrochalcones and S-benzylthiouronium chloride

Org. Commun. (2012) 5:1 ; 1 - 11
by K. L. Ameta , Biresh Kumar, Nitu S. Rathore and B. L. Verma

Various 4'-hydroxy-3',5'-dinitro substituted chalcones 1 and S-benzylthiouronium chloride (SBT) 2 in the presence of DMF-organic bases (morpholine/ pyrrolidine/ piperidine) gave 4,6-diaryl-2-(4-morpholinyl / 1-pyrrolidinyl /1-piperidinyl)- pyrimidines 4, 5and 6 in a facile one-pot conversion. In an another attempt reactants 1 and 2 yielded intermediate 2-benzylthiopyrimidines 3, in presence of DMF, which on treatment with heterocyclic secondary amines gave products 4, 5 and 6 in an alternate two-step process.

Keywords
Chalcone S-benzylthiouronium chloride heterocyclic secondary amines.
DETAILS PDF OF ARTICLE
© 2012 ACG Publications. All rights reserved.
Original Article

2) An efficient solvent-free synthesis of imidazolines and benzimidazoles using K 4[Fe(CN) 6] catalysis

Org. Commun. (2012) 5:1 ; 12 - 17
by Kabeer A. Shaikh and Vishal A. Patil

Imidazolines and Benzimidazoles have been efficiently synthesized in high yields by treatment of 1,2-diamine with aldehydes using the metal co-ordinate complex K 4[Fe(CN) 6] as a catalysis. The method was carried out under solvent free condition via oxidation of carbon-nitrogen bond. The process is green, mild and inexpensive.

Keywords
Aldehydes K 4[Fe(CN) 6] imidazolines benzimidazoles solvent free
DETAILS PDF OF ARTICLE
© 2012 ACG Publications. All rights reserved.
Original Article

3) Organotin(IV) compounds of n-propyl and isopropyl glutarate: their synthesis, spectral characterization and antibacterial activity

Org. Commun. (2012) 5:1 ; 18 - 26
by Javid Hussain, Hidayat Hussain, Viqar Uddin Ahmad, Ahmed Al-Harrasi and Amin Badshah

A series of new di- and triorganotin(IV) complexes of monoisopropyl and mono n-propyl glutarate have been synthesized and characterized by 1H- 13C- 119Sn-NMR, UV, IR and Mass spectrometry. The spectroscopic investigation demonstrated that the carboxylate group acts as a bidentate ligand in diorganotin(IV) and as a monodentate ligand in triorganotin(IV) compounds. Biological evaluation against various microorganisms indicates that the diorganotin(IV) complexes are slightly less reactive than triorganotin(IV) complexes.

Keywords
Organotin(IV) carboxylates spectroscopic studies biological activity .
DETAILS PDF OF ARTICLE
© 2012 ACG Publications. All rights reserved.
Original Article

4) Synthesis and characterization of new analogs of zafirlukast

Org. Commun. (2012) 5:1 ; 27 - 41
by Gilla Goverdhan , Anumula Raghupathi Reddy, N. Rama Krishna Reddy 1, Kurella Srinivas, Vurimidi Himabindu and Ghanta Mahesh Reddy

Design, synthesis and characterization of four novel series of Zafirlukast analogs are described. The modifications are substitution on indole nitrogen, C-5 position of indole moiety and amide nitrogen of zafirlukast.

Keywords
Zafirlukast anti asthma new analogs N-desmethyl zafirlukast analogs DCU analogs.
DETAILS PDF OF ARTICLE
© 2012 ACG Publications. All rights reserved.