JOURNAL 795


Organic Communications
VOLUME & ISSUE
Year: 2017 Issue: 1 January-March
PAGES
p.6 - 10
STATISTICS
Viewed 1475 times.
AUTHORS
    Nesa Ghasemi and Hasan Seçen
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A synthetic methodology for preparation of β-cyano-ʟ-alanine was developed via ʟ -serine. Esterification of ʟ -serine with MeOH, followed by protection of NH 2 with CBz, gave methyl 2-(benzyloxycarbonylamino)-3-hydroxypropanoate. Mesylation of OH group, and then cyanation, ester hydrolysis and removal of the CBz group with catalytic hydrogenation, gave β-cyano-ʟ-alanine. Crucial step for the synthesis of the title compound was cyanation with K 13CN.

KEYWORDS
  • β-cyano-ʟ-alanin e
  • labeled amino acid
  • asparagine

SUPPORTING INFORMATION


Supporting Information
Download File 2-OC-1608-502-SI.pdf (795.76 KB)