Synthesis of 13C labeled β-cyano-ʟ-alanine
Year: 2017 Issue: 1 January-March
p.6 - 10
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Nesa Ghasemi and Hasan Seçen
A synthetic methodology for preparation of β-cyano-ʟ-alanine was developed via ʟ -serine. Esterification of ʟ -serine with MeOH, followed by protection of NH 2 with CBz, gave methyl 2-(benzyloxycarbonylamino)-3-hydroxypropanoate. Mesylation of OH group, and then cyanation, ester hydrolysis and removal of the CBz group with catalytic hydrogenation, gave β-cyano-ʟ-alanine. Crucial step for the synthesis of the title compound was cyanation with K 13CN.KEYWORDS
- β-cyano-ʟ-alanin e
- labeled amino acid