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New Ergostane-type Sterol Produced by an Endophytic Fungus Fusarium phaseoli Isolated from Chisocheton macrophyllus (Meliaceae)

Original Article

JOURNAL 2387

Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 6 November-December
PAGES
p.614 - 621
DOI ADDRESS
http://doi.org/10.25135/rnp.334.2203.2387
STATISTICS
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AUTHORS
  • Aprilia Sari
  • Nurlelasari
  • Azmi Azhari
  • Desi Harneti P. Huspa
  • Rani Maharani
  • Tri Mayanti
  • Kindi Farabi
  • Darwati Darwati
  • Unang Supratman
  • Sofa Fajriah
  • Mohamad Nurul Azmi
  • Yoshihito Shiono
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new ergostane-type sterol, ergost-5,22E-dien-3β-oleate-20-ol (1), along with four known steroids, cerevisterol (2), atroside (3), ergosterol (4), and ergosterol peroxide (5) were isolated from the solid brown rice culture of the endophytic fungus Fusarium phaseoli, derived from the root of Chisocheton macrophyllus. The structures were determined by spectroscopic methods including 2D NMR techniques, MS, and chemical derivatization. Compounds 1-5 were evaluated their antibacterial activities against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 11229, the result showed no activities.

 KEYWORDS
  • Fusarium phaseoli
  • Chisocheton macrophyllus
  • Steroid
  • Antibacterial Activity

SUPPORTING INFORMATION

Supporting Information
Download File A10-334-RNP-2203-2387-SI.pdf (1.65 MB)