JOURNAL 3409
Records of Natural Products
VOLUME & ISSUE
Year: 2025 Issue: 3 May-June
Year: 2025 Issue: 3 May-June
PAGES
p.296 - 301
p.296 - 301
STATISTICS
Viewed 244 times.
Viewed 244 times.
GRAPHICAL ABSTRACT
ABSTRACT
Chemical investigations of Platycodon grandiflorus have resulted in the isolation and identification of seven 8,4'-oxyneolignans, including four undescribed compounds (1-4). The structures of these novel compounds were determined using HR-ESI-MS and NMR (1D and 2D) spectroscopic analyses, combined with ECD calculations. The inhibitory activity of these terpenoids against α-glucosidase was also evaluated, and the results revealed that none of the compounds exhibited significant α-glucosidase inhibitory activity at a concentration of 50 μM. Compared with the positive control, all the compounds displayed weak inhibitory activity, with inhibition rates ranging from 1.06% to 7.31%.
KEYWORDS- Platycodon
- Platycodon grandiflorus
- apha-glucosidase
- chemical constituents
- 8,4-oxyneolignan.
