An Undescribed Zhepiresionol Analogue from Ailanthus altissima

Short Report

JOURNAL 3520

Records of Natural Products

VOLUME & ISSUE

Year: 2025 Issue: 5 September-October

PAGES

p.627 - 632

DOI ADDRESS

http://doi.org/10.25135/rnp.538.2505.3520

STATISTICS

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AUTHORS

Yu-Ting Mu
Li Huang
Yi Li
Yun Deng
De-Feng Peng

GRAPHICAL ABSTRACT

ABSTRACT

This study involved the extraction, isolation, structural elucidation of a new analogue of zhepiresionol, as well as five lignans previously identified, from the plant Ailanthus altissima (Mill.) Swingle. The structural elucidation was accomplished through comprehensive analyses of various spectroscopic data, which included HRESIMS, UV, IR, and NMR, along with a comparison of ECD curves. At a concentration of 15 µM, Compound 1 showed the capacity to suppress IL-1β and IL-6 expression in RAW 264.7 cells that were Lipopolysaccharide-stimulated.

KEYWORDS

Ailanthus altissima
zhepiresionol analogue
anti-inflammatory activity

SUPPORTING INFORMATION

Supporting Information

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