JOURNAL 3552
Records of Natural Products
Year: 2025 Issue: 6 November-December
p.728 - 733
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Ximiao Yang
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Wenting Chen
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Yuxiao Li
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Ziliang Wang
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Yanhong Li
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Yihuai Liang
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Xishan Bai
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Xiangzhong Huang
GRAPHICAL ABSTRACT
ABSTRACT
To discover new secondary metabolites and reveal the anti-inflammation effective ingredients of Heracleum rapula, a phytochemical investigation was performed, leading to one new enynic ester, heracleumate (1), and four polyacetylene diols, 9-epoxyfalcarindiol (2), 3(R), 8(S)-falcarindiol (3), oplopantriol B (4), and 18-Oacetyloplopantriol B (5) were isolated and identified. Their structures were established by spectroscopic analysis. Compounds 1, 2, 4, and 5 exhibited NO inhibition activities with IC50 values of 48.1 ± 1.9, 95.8 ± 6.2, 18.9 ± 2.0, and 88.7 ± 7.1 μM in RAW 264.7 cells treated with lipopolysaccharide. Among them, oplopantriol B (4) exhibited the best NO inhibition activity. Additionally, compounds 1, 2, and 4 can significantly reduce the levels of inflammatory cytokines, including COX-1, IL-6, iNOS, and TNF-α.
KEYWORDS- Heracleum rapula Franch.
- enynic ester
- polyacetylene diol
- anti-inflammation
