Organic Communications Articles
Issue: 1 January-March
Year: 2010 Volume: 3 Issue:1 January-March
1) Ionic liquid catalyzed multicomponent synthesis of 3,4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine derivatives
An efficient and novel one-pot synthesis of 3,4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine derivatives from 1-naphthol, various anilines and formalin at room temperature stirring. The six-membered N,O-heterocyclic skeleton was constructed via 1-benzyl-3-methyl imidazolium hydrogen sulphate [bnmim] [HSO4] promoted Mannich type reaction.Keywords 1 3-oxazines ionic liquid Mannich type reaction multicomponent reaction DETAILS PDF OF ARTICLE © 2010 ACG Publications. All rights reserved.
2) A convenient one pot preparation of 4-thiazolidinones from enaminolactones
Enaminones 3 and 4, precursors of 4-thiazolidinones, were prepared by condensing tetronic acid (1a) and 4-hydroxy 6-methyl pyrone (1b) respectively with thiosemicarbazide derivatives 2 in refluxing ethanol. The 4-thiazolidinones 6, 7 derivatives were obtained by reacting compounds 3 or 4 with ethyl 2- bromo propionate 5 in the presence of anhydrous sodium acetate in ethalonic medium. Similarly, 9 products were synthesized by action of benzyl 2-bromo acetate 8 on 3.Keywords Pyrones tetronic acid thiosemicarbazides enaminones thiazolidinones DETAILS PDF OF ARTICLE © 2010 ACG Publications. All rights reserved.
3) Synthesis, Spectral characterization and antimicrobial activity of 2-(substituted)-2,2-[1,3- dihydro-(3,4-1,2,5-oxadiazolediyl) diaza][5 ׳ , 5 ׳ -dimethyl-1 ׳ , 3 ׳ -propanediyl) dioxy] phosphoranes
The cyclic oxadiazolediyl dioxachlorophosphine precursor on subsequent reaction with various alcohols underwent halide displacement to give 2-substituted diaza phospholes. These phospholes on oxidative addition with di hydroxy alcohols form corresponding phosphoranes The antimicrobial activities of these compounds were evaluated and they exhibited significant antimicrobial activity.Keywords Spirophosphoranes dioxaphosphoranes antimicrobial activity P(III) to P(V) N-chlorodiisopropylamine. DETAILS PDF OF ARTICLE © 2010 ACG Publications. All rights reserved.