Organic Communications Articles
Issue: 3 July-September
Year: 2012 Volume: 5 Issue:3 July-September
1) A brief review on synthesis & applications of β-enamino carbonyl compounds
Owing to the wide range applications of β-enamino esters (enamines of β–dicarbonyl compounds) in pharmaceuticals and as building blocks for the synthesis of a variety of heterocyclic compounds, β-amino esters, β-amino acids, γ-amino alcohols, peptides and alkaloids a number of methods have been developed so far for the synthesis of these compounds. Due to the importance of these compounds as intermediates in organic synthesis, a concised review is presented.Keywords Building blocks concised review β-enamino esters heterocyclic and intermediates in organic synthesis. DETAILS PDF OF ARTICLE © 2012 ACG Publications. All rights reserved.
2) A simple and efficient protocol for the synthesis of quinolines catalyzed by chloramine-T
Chloramine-T has been proved as an efficient catalyst for the synthesis of substituted quinolines. In this method, 2-amino aryl ketones were smoothly reacted with ketones to afford the corresponding quinoline derivatives in very good yields. All the reactions were carried out at acetonitrile reflux.Keywords 2-Amino aryl ketones ketones chloramine-T quinolines. DETAILS PDF OF ARTICLE © 2012 ACG Publications. All rights reserved.
3) Synthesis of some novel 4-aza-tricyclo[5.2.2.02,6 ]undecane-3,5,8- triones from 2-trimethylsilyloxy-1,3-cyclohexadiene and 1-methoxy-1,3-cyclohexadiene
The synthesis and characterization of nine novel Diels-Alder cycloadducts: the 4-azatricyclo[5.2.2.02,6] undecane-3,5,8-triones using 2-trimethylsilyloxy-1,3-cyclohexadiene and 1-methoxy-1,3- cyclohexadiene is reported. The isolated yields of the pure cycloadducts range between 75 to 95%.Keywords Diels-Alder reaction 1 3-cyclohexadienes maleimides cycloadducts 4-aza-tricyclo[5.2.2.02 6] undecane-3 5 8-triones. DETAILS PDF OF ARTICLE © 2012 ACG Publications. All rights reserved.
4) Synthesis and spectroscopic characterization of pyrrole-2,3- diones and their following reactions with 1,2-aromatic diamines
4-aroyl-5-aryl-2,3-furandiones and N,N-dialkyl urea combine with loss of water yielding the pyrrole2,3-dione derivatives in moderate yields (47-68%). Then, these compounds were converted into 2(1H)- quinoxalinones with various 1,2-phenylenediamines. The structures and characterizations of the synthesized compounds were established by the 1H- and 13C-NMR, IR and elemental analysis.Keywords Furan-2 3-dione Pyrrole-2 3-dione Quinoxaline 1 2-phenylenediamine. DETAILS PDF OF ARTICLE © 2012 ACG Publications. All rights reserved.
5) A facile one-pot synthesis of thiazoles and thiazolyl-pyrazole derivatives via multicomponent approach
Thiazoles and thiazolyl-pyrazole derivatives have been efficiently synthesized under neat reaction conditions in excellent yields. Condensation of 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one (1), thiosemicarbazide (2) and various carbonyl compounds (3 & 5) gave corresponding thiazole (4) and thiazolylpyrazole derivatives (6) in excellent yields by using Hantzsch-Thiazole synthesis. The main advantage of this method is the short reaction time, high yields, simple workup and environmental benign process. The structures of newly synthesized compounds have been established by elemental analysis and spectral data.Keywords Thiazole thiazolyl-pyrazole 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one multicomponent approach one-pot DETAILS PDF OF ARTICLE © 2012 ACG Publications. All rights reserved.
6) KHSO4-SiO2 catalyzed facile synthesis of bis(indolyl)methanes
This work presents a highly efficient and simple method for the synthesis of bis(indolyl)methanes, catalyzed by KHSO4-SiO2 with excellent yields. Various substituted aldehydes with indole under this reaction condition is elucidated. This method is an environmentally benign, efficient reaction, requires shorter reaction time and simple experimental and workup procedures.DOI Keywords KHSO4-SiO2 aldehydes indole bisindolylmethanes solvent-free reaction. DETAILS PDF OF ARTICLE © 2012 ACG Publications. All rights reserved.