Records of Natural Products

A scientific open access journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Editor-in-Chief: Ahmet C Goren

LATEST ARTICLES

Short Report

A Novel Limonoid from the Seeds of Chisocheton macrophyllus

Rec. Nat. Prod. (2024) in press ; 1 - 6
by Nurlelasari , Muhammad Huda , Wahyu Safriansyah , Unang Supratman , Yudha Budiman , Desi Harneti P. Huspa , Rani Maharani , Tri Mayanti , Kindi Farabi and Sofa Fajriah

This study aimed to isolate a novel limonoid compound, (6R,7S, 8R, 9R, 10R, 11R, 13S, 17R)-17-(furan-3-yl) -4, 4, 8, 10, 13-pentamethyl-3-oxo-4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17-dodecahydro-3H-cyclopenta[a]phenanthrene-6,7,11-triyltriacetate (11α-acetoxydysobinin) (1), and 3 pre-existing limonoids, namely dysobinin (2), dysobinol (3), and 7-deacetylepoxyazadiradione (4) from the seeds of Chisocheton macrophyllus (Meliaceae). In addition, the structure of the isolated compounds was determined using various spectroscopic techniques, including UV, IR, HRTOFMS, 1D, and 2D NMR. The cytotoxic effects of each compound were then evaluated against breast cancer cells of the Michigan Cancer Foundation-7 (MCF-7), but no significant activity was observed.

DOI
http://doi.org/10.25135/rnp.451.2311.2960
Keywords
Chisocheton macrophyllus Meliaceae limonoid cytotoxic activity MCF-7
Available online: March 17, 2024
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Original Article

A New Butoxy Substituted Indolediketopiperazine from the Marine Derived Fungus Aspergillus sp. 66may

Rec. Nat. Prod. (2024) in press ; 1 - 8
by Jing Xia , Jianhui Liu , Yuanqian Wang , Shumei Shen , Xiaoxian Song , Guangtao Zhang and Minghe Luo

A new butoxy substituted indolediketopiperazine (1), together with five known indolediketopiperazines (26), which are derivatives of brevianamides, were isolated from the marine derived fungus Aspergillus sp. 66may. Careful analysis and comparison of the HRESIMS, as well as 1D and 2D NMR datasets, identified the structures of the isolated compounds. The subsequent antibacterial and anti-inflammatory activities showed that compound 4 possessed antimicrobial bioactivities against Bacillus subtilis ATCC 39620 with minimum inhibitory concentration (MIC) value of 64 μg/mL. Compounds 1, 2, 4 exhibited potential inhibitory activities against NO production with IC50 value of 28.2, 21.3, 23.6 μM, respectively. It seems that butoxy substitution at C-9 in brevianamides have little effects on their antimicrobial and anti-inflammatory bioactivities.

DOI
http://doi.org/10.25135/rnp.450.2401.3022
Keywords
Diketopiperazines brevianamide antibacterial activity anti-inflammatory
Available online: March 15, 2024
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Short Report

A New Prenylated Coumarin from the Roots of Toddalia asiatica

Rec. Nat. Prod. (2024) in press ; 1 - 6
by Aifen Zeng , Zhengkuan Zhang , Guobo Xu , Shanggao Liao , Qin-Feng Zhu and Xun He
A new prenylated coumarin, 5, 7-dimethoxy-6-[(Z)-3'-methylbutan-1',3'-d-ienyl] coumarin (1), along with ten known compounds (2-11), was obtained from the roots of Toddalia asiatica (Linn.) Lam. Their structures were determined based on 1 D and 2 D NMR spectroscopy as well as high-resolution mass spectrometry. Notably, the structure of (3S, 4R)-3,4-epoxypimpinellin was revised as its cis-epimer, compounds (2-7) were isolated from this genus for the first time. The cytotoxic activities of the isolated compounds 1-11 were evaluated against SW480, A549, MDA-MB-231, HepG 2, HEp-2, SGC7901 cancer cell lines. Compound 10 exhibited weak cytotoxicity against HEP 2 with IC50 value of 75.19 ± 1.17 µM.
DOI
http://doi.org/10.25135/rnp.449.2401.3015
Keywords
Toddalia asiatica coumarins chemical constituents cytotoxic activity
Available online: March 14, 2024
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Original Article

Alchemilla pseudocartalinica Juz: Phytochemical Screening by UPLC-MS/MS, Molecular Docking, Anti-oxidant, Anti-diabetic, Anti-glaucoma, and Anti-Alzheimer Effects

Rec. Nat. Prod. (2024) in press ; 1 - 22
by Leyla Guven , Adem Ertürk , Mustafa Abdullah Yılmaz , Saleh H. Alwasel and İlhami Gülçin

Alchemilla species (Rosaceae) are popularly known as ‘Lady’s Mantle, Lion’s claw’ and are used for medicinal purposes as diuretic, laxative, tonic, and wound healing agents. Bioactivities and phenolic content of Alchemilla pseudocartalinica Juz. species have yet to be investigated. Our research focused on assessing the antioxidant characteristics of A. pseudocartalinica methanol (MEAP) and water extracts (WEAP), as well as their inhibitory effects on acetylcholinesterase (AChE), α-glycosidase (α-gly), and human carbonic anhydrase II (hCA II) enzymes. Additionally, we conducted chemical characterization using UPLC-MS/MS and investigated the correlation between major phenolic compounds and enzymes through molecular docking analysis. To assess the antioxidant activities of the MEAP and WEAP, six test systems were employed, including DPPH, ABTS, DMPD, FRAP, CUPRAC, and Fe3+ reducing assays. The outcome showed that the methanol extract of the plant generally has stronger antioxidant activity. In addition, UPLC-MS/MS analysis indicated, miquelianin (44.095 mg/g), quinic acid (17.054 mg/g), and ellagic acid (6.492 mg/g) were significant in the methanol extract. A molecular docking study revealed a significant affinity for binding between the hCAII enzyme and quinic acid, miquelianin, and AChE/α-gly enzymes. A. pseudocatalinica methanol and water extracts have high antioxidant activity and good inhibition effect against AChE, α-glycosidase, and hCA II enzymes.

DOI
http://doi.org/10.25135/rnp.448.2312.2993
Keywords
Alchemilla antioxidant activity enzyme inhibition UPLC-MS/MS molecular docking
Available online: March 09, 2024
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