JOURNAL 988


Records of Natural Products
VOLUME & ISSUE
Year: 2019 Issue: 3 May-June
PAGES
p.216 - 225
STATISTICS
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AUTHORS
    Tuba Aydın, Bayram Yurtvermez, Murat Şentürk, Cavit Kazaz and Ahmet Çakır
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Tarragon or Dragon's-wort (Artemisia dracunculus L.) is widely used as spice and in traditional medicine in various regions of the world. Inhibitory effects of the n-hexane, dichloromethane, ethanol and methanol extracts of the leaves of tarragon on the human carbonic anhydrase (hCA) I and II enzymes were investigated. Dichloromethane extract exhibited the strongest activity with lowest IC50 value (0.020 and 0.031 μg/mL, respectively). The chromatographic studies on the dichloromethane extract of tarragon allowed the isolation of six known strong inhibitors of hCA isozymes as trans-anethole, stigmasterol, herniarin, (2E,4E)-N-isobutylundeca-2,4-dien-8,10-diynamide, (2E,4E)-1-(piperidin-1-yl)undeca-2,4-diene-8,10-diyn-1-one and 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane. The compound, 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane was isolated from tarragon for the first time in this study. Among the tested compounds, 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane showed the highest inhibitiory impact on both hCA isozymes. Also its IC50 values were found lower than positive control, acetazolamide.

KEYWORDS
  • Artemisia dracunculus L.
  • 1-(4'-methoxyphenyl)-1
  • 2
  • 3-trihydroxypropane
  • enzyme inhibition
  • hCA I
  • hCA II.

SUPPORTING INFORMATION


Supporting Information
Download File 102-RNP-1807-329-SI.pdf (913.26 KB)