JOURNAL 3663
Records of Natural Products
VOLUME & ISSUE
Year: 2026 Issue: 2
Year: 2026 Issue: 2
PAGES
p.4 - 4
p.4 - 4
STATISTICS
Viewed 21 times.
Viewed 21 times.
AUTHORS
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Nguyen Hoang Phuc
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Vu Thi Ngan Ly
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Duong Thi Thuy
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Nguyen Thi Minh Hang
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Tai Bui Huu
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Tran Huu Giap
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Ngo Quoc Anh
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Phan Van Kiem
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Nguyen Xuan Nhiem
GRAPHICAL ABSTRACT
ABSTRACT
Two new phloroglucinol glucosides, spiruplatosides A (1) and B (2) along with six known compounds, including 5,7-dimethoxyflavone (3), 5-hydroxy-7,4'-dimethoxyflavone (4), 5,7,4'-dimethoxyflavone (5), terephthalic acid dimethyl ester (6), terephthalic acid-(2-hydroxyethyl ester)-methyl ester (7), 13S-hydroxy-9Z,11E-octadecadienoic acid (8) were isolated from the microalgae Spirulina platensis. Compounds 1–8 were evaluated for cytotoxic activity against SK-LU-1 and HepG2 cancer cells. Compounds 1 and 2 were the most active with IC₅₀ values ranging from 1.40 to 3.66 μM. Compounds 4 and 5 showed moderate effects with IC50 values ranging from 66.09 to 74.46 μM.
KEYWORDS- Spirulina platensis
- microalgae
- spiruplatoside
- phloroglucinol glucoside
- cytotoxic activity
