Two undescribed phenylpropanoid derivatives from Notopterygium incisum roots with anti-inflammatory potential

Short Report

JOURNAL 3718

Records of Natural Products

VOLUME & ISSUE

Year: 2026 Issue: 2

PAGES

p.3 - 3

DOI ADDRESS

http://doi.org/10.25135/rnp.2511.3718

STATISTICS

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AUTHORS

Fei-Yuan Deng
Li-Lian Zhao
Li Huang
Peng Tan
Yun Deng
Li-jun Huang

GRAPHICAL ABSTRACT

ABSTRACT

Two previously undescribed phenylpropanoid derivatives, including a terpenylated coumarin (1) and a ferulic acid analogue (2), were isolated from the roots of Notopterygium incisum (Umbelliferae). Their structures were successfully established using spectroscopic techniques, including mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) spectroscopy. In vitro anti-inflammatory assay using a lipopolysaccharide-stimulated RAW264.7 macrophages indicated compounds 1 and 2 showed anti-inflammatory potential by inhibiting the secretion of NO at the concentra-tion of 7.5 μM.

KEYWORDS

Notopterygium incisum
phenylpropanoid derivatives
nitric oxide
anti-inflammatory

SUPPORTING INFORMATION

Supporting Information

Download File RNP-2511-3718-SI.pdf (4.28 MB)