Organic Communications Articles
Issue: 1 January-March
Year: 2016 Volume: 9 Issue:1 January-March
1) Stereoselective synthesis of C1-C24 fragment of antanapeptin-A
The stereoselective synthesis of the (C1-C24) fragment of Antanapeptin–A is described. The required stereochemistry of b -hydroxy- a -methyl acid unit was accomplished through Aldol reaction using Evans’ chiral auxiliary followed by the installation of terminal alkyne with Ohira–Bestmann reagent.Keywords Antanapeptin A Aldol Reaction Stereo selective synthesis Peptide Evans’ auxiliary DETAILS PDF OF ARTICLE © 2016 ACG Publications. All rights reserved.
2) Transfer hydrogenation of a carbonyl compound in glycerol-based solvent mixtures
Three representative carbonyl compounds were efficiently hydrogenated in a glycerol-triac etin e or glycerol-tributyrin mixture. The addition of triacetin to glycerol favorably altered the polarity of the reaction mixture, thereby increasing the solubility of reactants and, in turn, reactant conversion rates. Maximum conversion was detected in an 80%-20% a glycerol-triacetin mixture ( 80 :2 0 ) in the presence of a Ru(p-cymene)Cl 2-dimer catalyst.Keywords Glycerol triacetin green chemistry and sustainable solvent DETAILS PDF OF ARTICLE © 2016 ACG Publications. All rights reserved.
3) Synthesis of ester functionalized 2-pyridone derivatives using KF/Alumina as a catalyst
A simple and efficient method for synthesis of ester functionalized 2-pyridone derivatives (4a-m) via tri component reaction of primary amine, mono ester acetylene and diester acetylene using KF/alumina as catalyst under microwave irradiation is reported.Keywords KF/alumina ester functionalized 2-pyridones primary amine acetylenic ester microwave irradiation DETAILS PDF OF ARTICLE © 2016 ACG Publications. All rights reserved.
4) Simple synthesis of non-symmetric 1,4-dialkoxybenzenes via 4-alkoxyphenols
A three steps synthesis of non-symmetric 1,4-dialkoxybenzenes starting from 4-hydroxybenzaldehydes was described. At first step 4-alkoxyphneols were alkylated to give 4-alkoxybenzaldehydes. At the second step 4-alkoxybenzaldehydes were submitted to a Baeyer-Villiger oxidation with 30% H 2O 2 to afford 4-alkoxyphenols. At the last step 4-alkoxyphenols were secondly alkylated to give the title compounds.Keywords 4-alkoxyphenols 1 4-dialkoxybenzenes monomer PPV synthesis DETAILS PDF OF ARTICLE © 2016 ACG Publications. All rights reserved.